People
Kreder KJ (Kreder K)
Publications
Erickson BA, Griffith JW, Wensheng G, Mengying Y, Herman T, Bradley CS, Quentin Clemens J, Farrar JT, Gupta P, Kreder KJ, Henry Lai H, Naliboff BD, Newman DK, Rodriguez LV, Spitznagle T, Sutcliffe S, Sutherland SE, Taple BJ, Richard Landis J. Ecological Momentary Assessment of Pelvic Pain and Urinary Urgency Variability in Urologic Chronic Pelvic Pain Syndrome and Their Association with Illness Impact and Quality of Life: Findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Symptom Patterns Study. Neurourol Urodyn. 2024 Apr;43(4):893-901. doi: 10.1002/nau.25363. Epub 2024 Jan 22. [PMID: 38247366] [PMC11031348]
Keywords: ecological momentary assessment; illness impact; phone application; quality of life; urologic chronic pelvic pain syndrome; variability.Clemens JQ, Locke K Jr, Landis JR, Kreder K, Rodriguez LV, Yang CC, Tu FF, Harte SE, Schrepf A, Farrar JT, Sutcliffe S, Naliboff BD, Williams DA, Afari N, Spitznagle T, Taple BJ, Lai HH; Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. Validation of a simple body map to measure widespread pain in urologic chronic pelvic pain syndrome: A MAPP research network study. Neurourol Urodyn. 2024 Mar;43(3):727-737. doi: 10.1002/nau.25400. Epub 2024 Jan 25. [PMID: 38270336] [PMC10981467]
Keywords: chronic prostatitis with chronic pelvic pain syndrome; interstitial cystitis/bladder pain syndrome; pelvic pain; prostate; urinary bladder.- Lutgendorf SK, Zia S, Luo Y, O'Donnell M, van Bokhoven A, Bradley CS, Gallup R, Pierce J, Taple BJ, Naliboff BD, Quentin Clemens J, Kreder KJ, Schrepf A. Early and Recent Exposure to Adversity, TLR-4 Stimulated Inflammation, and Diurnal Cortisol in Women with Interstitial Cystitis/Bladder Pain Syndrome: A MAPP Research Network Study. Brain Behav Immun. 2023 Jul;111:116-123. doi: 10.1016/j.bbi.2023.03.024. Epub 2023 Mar 29. [PMID: 37001828] [PMC10474614]
Keywords: Chronic stress; Cortisol; Early life adversity; HPA axis; IC/BPS; Inflammation; Interstitial cystitis; Pain; Recent life adversity. - Stephens-Shields AJ, Lai HH, Landis JR, Kreder K, Rodriguez LV, Naliboff BD, Afari N, Sutcliffe S, Moldwin R, Griffith JW, Clemens JQ, Bradley CS, Quallich S, Gupta P, Harte SE, Farrar JT. Clinically Important Differences for Pain and Urinary Symptoms in Urological Chronic Pelvic Pain Syndrome: A MAPP Network Study. J Urol. 2023 Jun;209(6):1132-1140. doi: 10.1097/JU.0000000000003394. Epub 2023 Feb 27. [PMID: 36848118] [PMC11062515]
Keywords: cystitis, interstitial; minimal clinically important difference; pelvic pain; research design; treatment outcome. - Schrepf A, Kaplan C, Harris RE, Williams DA, Clauw DJ, As-Sanie S, Till S, Clemens JQ, Rodriguez LV, Van Bokhoven A, Landis R, Gallop R, Bradley C, Naliboff B, Pontari M, O'Donnell M, Luo Y, Kreder K, Lutgendorf SK, Harte SE. Stimulated whole-blood cytokine/chemokine responses are associated with interstitial cystitis/bladder pain syndrome phenotypes and features of nociplastic pain: a multidisciplinary approach to the study of chronic pelvic pain research network study. Pain. 2023 May 1;164(5):1148-1157. doi: 10.1097/j.pain.0000000000002813. [PMID: 36279178] [PMC10106356]
Keywords: Chronic pain; Interstitial cystitis/bladder pain syndrome; toll-like receptor. - Farrar JT, Locke KT Jr., Clemens JQ, Griffith JW, Harte SE, Kirkali Z, Kreder KJ, Krieger JN, Lai HH, Moldwin RM, Mullins C, Naliboff BD, Pontari MA, Rodriguez LV, Schaeffer AJ, Schrepf A, Stephens-Shields A, Sutcliffe S, Taple BJ, Williams DA, Landis JR. Widespread Pain Phenotypes Impact Treatment Efficacy Results in Randomized Clinical Trials for Interstitial Cystitis/Bladder Pain Syndrome: A MAPP Network Study. Res Sq. 2023 Feb 23;rs.3.rs-2441086. doi: 10.21203/rs.3.rs-2441086/v1. Preprint [PMID: 36865104] [PMC9980200]
Keywords: Randomized controlled trials; Chronic pain; Epidemiology; Functional clustering. - Bradley CS , Gallop R , Sutcliffe S, Kreder KJ, Lai HH, Clemens JQ, Naliboff BD, for the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. Long-term Symptom Trajectories in Urologic Chronic Pelvic Pain Syndrome: A MAPP Research Network Study. Urology. 2022 Nov;169:58-64. doi: 10.1016/j.urology.2022.07.045. Epub 2022 Aug 9. [PMID: 35961564] [PMC10590538]
Keywords: Chronic prostatitis; extended follow-up; interstitial cystitis; MAPP network cohort study; urologic chronic pelvic pain syndrome; bladder pain syndrome. - Schrepf A, Gallop R, Naliboff B, Harte SE, Afari N, Lai HH, Pontari M, McKernan LC, Strachan E, Kreder KJ, As-Sanie SA, Rodriguez LV, Griffith JW, Williams DA; Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. Clinical Phenotyping for Pain Mechanisms in Urologic Chronic Pelvic Pain Syndromes: A Mapp Research Network Study. J Pain. 2022 Sep;23(9):1594-1603. doi: 10.1016/j.jpain.2022.03.240. Epub 2022 Apr 25. [PMID: 35472518] [PMC10547025]
Keywords: Nociceptive pain; central nervous system sensitization; chronic pain; cystitis; neuropathic pain. - Gupta P, Gallop R, Spitznagle T, Lai H, Tu F, Krieger JN, Clemens JQ, Bradley CS, Yang C, Sutcliffe S, Moldwin R, Kreder K, Kutch J, Rodriguez LV. Is Pelvic Floor Muscle Tenderness a Distinct Urologic Chronic Pelvic Pain Syndrome Phenotype? Findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Symptom Pattern Study. J Urol. 2022 Aug;208(2):341-349. doi: 10.1097/JU.0000000000002679. Epub 2022 Mar 28. [PMID: 35344391] [PMC10123541]
Keywords: chronic prostatitis with chronic pelvic pain syndrome; cystitis; interstitial; pelvic pain. - Quallich SA, Quentin Clemens J, Ronstrom C, James AS, Kreder KJ, Henry Lai H, Naliboff BD, Rodriguez LV, Berry SH, Sutcliffe S. Flares and their impact among male urologic chronic pelvic pain syndrome patients: An in-depth qualitative analysis in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. Neurourol Urodyn. 2022 Aug;41(6):1468-1481. doi: 10.1002/nau.24983. Epub 2022 Jun 10. [PMID: 35686553] [PMC11033701]
Keywords: chronic prostatitis; diet; focus group; pelvic pain; prostatitis; quality of life; symptom exacerbation; urinary bladder. - Mawla I, Schrepf A, Ichesco E, Harte SE, Klumpp DJ, Griffith JW, Strachan E, Yang CC, Lai H, Andriole G, Magnotta VA, Kreder K, Clauw DJ, Harris RE, Clemens JQ, Landis JR, Mullins C, Rodriguez LV, Mayer EA, Kutch JJ. Natural bladder filling alters resting brain function at multiple spatial scales: a proof-of-concept MAPP Network Neuroimaging Study. Sci Rep. 2020 Nov 16;10(1):19901. doi: 10.1038/s41598-020-76857-x. [PMID: 33199816] [PMC7669903]
Keywords: bladder; functional magnetic resonance imaging. - Clemens JQ, Kutch JJ, Mayer EA, Naliboff BD, Rodriguez LV, Klumpp DJ, Schaeffer AJ, Kreder KJ, Clauw DJ, Harte SE, Schrepf AD, Williams DA, Andriole GL, Lai HH, Buchwald D, Lucia MS, van Bokhoven A, Mackey S, Moldwin RM, Pontari MA, Stephens-Shields AJ, Mullins C, Landis JR. The Multidisciplinary Approach to The Study of Chronic Pelvic Pain (MAPP) Research Network*: Design and implementation of the Symptom Patterns Study (SPS). Neurourol Urodyn. 2020 Aug;39(6):1803-1814. doi: 10.1002/nau.24423. Epub 2020 Jun 23. [PMID: 32578257] [PMC8025696]
Keywords: chronic; interstitial cystitis; plasma biomarkers; prostatitis; urine biomarkers; urological chronic pelvic pain syndromes. - Cui X, Jing X, Lutgendorf SK, Bradley CS, Schrepf A, Erickson BA, Magnotta VA, Ness TJ, Kreder KJ, O'Donnell MA, Luo Y. Cystitis-induced bladder pain is Toll-like receptor 4 dependent in a transgenic autoimmune cystitis murine model: a MAPP Research Network animal study. Am J Physiol Renal Physiol. 2019 Jul 1;317(1):F90-F98. doi: 10.1152/ajprenal.00017.2019. Epub 2019 May 15. [PMID: 31091120] [PMC6692719]
Keywords: Toll-like receptor 4; cystitis; model; pain. - Schrepf A, Naliboff B, Williams DA, Stephens-Shields AJ, Landis JR, Gupta A, Mayer E, Rodriguez LV, Lai H, Luo Y, Bradley C, Kreder K, Lutgendorf SK; MAPP Research Network. Adverse childhood experiences and symptoms of urologic chronic pelvic pain syndrome: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Study. Ann Behav Med. 2018 Sep 13;52(10):865-877. doi: 10.1093/abm/kax060. [PMID: 30212850] [PMC6135957]
Keywords: Interstitial Cystitis/Painful Bladder Syndrome; Chronic Prostatitis with Chronic Pelvic Pain Syndrome; Psychological Trauma; Sexual Abuse. - Sutcliffe S, Jemielita T, Lai HH, Andriole GL, Bradley CS, Clemens JQ, Gallop R, Hooton TM, Kreder KJ, Krieger JN, Kusek JW, Labus J, Lucia MS, Mackey S, Naliboff BD, Robinson NA, Rodriguez LV, Stephens-Shields A, van Bokhoven A, Wolin KY, Yan Y, Yang CC, Landis JR, Colditz GA; MAPP Research Network. A case-crossover study of urological chronic pelvic pain syndrome flare triggers in the MAPP Research Network. J Urol. 2018 May;199(5):1245-1251. doi: 10.1016/j.juro.2017.12.050. Epub 2017 Dec 27. [PMID: 29288643] [PMC5911194]
Keywords: cystitis; interstitial; prostatitis; surveys and questionnaires; symptom flare up; urinary bladder. - Kogan P, Xu S, Wang Y, O'Donnell MA, Lutgendorf SK, Bradley CS, Schrepf A, Kreder KJ, Luo Y. Sub-noxious Intravesical lipopolysaccharide triggers bladder inflammation and symptom onset in a transgenic autoimmune cystitis model: A MAPP Network Animal Study. Sci Rep. 2018 Apr 26;8(1):6573. doi: 10.1038/s41598-018-24833-x. [PMID: 29700406] [PMC5919907]
Keywords: autoimmunity; experimental models of disease. - Kutch JJ, Ichesco E, Hampson JP, Labus JS, Farmer MA, Martucci KT, Ness TJ, Deutsch G, Apkarian AV, Mackey SC, Klumpp DJ, Schaeffer AJ, Rodriguez LV, Kreder KJ, Buchwald D, Andriole GL, Lai HH, Mullins C, Kusek JW, Landis JR, Mayer EA, Clemens JQ, Clauw DJ, Harris RE; MAPP Research Network. Brain signature and functional impact of centralized pain: a multidisciplinary approach to the study of chronic pelvic pain (MAPP) network study. Pain. 2017 Oct;158(10):1979-1991. doi: 10.1097/j.pain.0000000000001001. [PMID: 28692006] [PMC5964335]
Keywords: Centralized; Chronic; Pain; fMRI; Widespread; Fibromyalgia; Pelvic; VBM; Connectivity. - Lai HH, Jemielita T, Sutcliffe S, Bradley CS, Naliboff B, Williams DA, Gereau RW 4th, Kreder K, Clemens JQ, Rodriguez LV, Krieger JN, Farrar JT, Robinson N, Landis JR; MAPP Research Network. Characterization of whole-body pain in urological chronic pelvic pain syndrome at baseline: A MAPP Research Network Study. J Urol. 2017 Sep;198(3):622-631. doi: 10.1016/j.juro.2017.03.132. Epub 2017 Mar 31. [PMID: 28373134] [PMC5562525]
Keywords: cystitis; interstitial; pelvic pain; prostate; prostatitis; urinary bladder. - Wang X, Liu W, O'Donnell M, Lutgendorf S, Bradley C, Schrepf A, Liu L, Kreder K, Luo Y. Evidence for the role of mast cells in cystitis-associated lower urinary tract dysfunction: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Animal Model Study. PLoS One. 2016 Dec 21;11(12):e0168772. doi: 10.1371/journal.pone.0168772. eCollection 2016. [PMID: 28002455] [PMC5176179]
Category: Mast cells; Bladder; Cystitis; Mouse models; Inflammation; Urination; Habits; Pain. - Xu S, Wang X, Wang Y, Lutgendorf S, Bradley C, Schrepf A, Kreder K, O'Donnell M, Luo Y. Transgenic mice expressing mcp-1 by the urothelium demonstrate bladder hypersensitivity, pelvic pain and voiding dysfunction: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Animal Model Study. PLoS One. 2016 Sep 29;11(9):e0163829. doi: 10.1371/journal.pone.0163829. eCollection 2016. [PMID: 27684718] [PMC5042429]
Keywords: Bladder; Mouse models; Inflammation; Pain; Genetically modified animals; Cystitis; Habits; Urination. - Schrepf A, O'Donnell MA, Luo Y, Bradley CS, Kreder KJ, Lutgendorf SK. Inflammation and symptom change in interstitial cystitis or bladder pain syndrome: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Study. Urology. 2016 Apr;90:56-61. doi: 10.1016/j.urology.2015.12.040. Epub 2016 Jan 6. [PMID: 26768711] [PMC4892365]
Keywords: Interstitial Cystitis, Inflammation, Toll-Like Receptor 2, Toll-Like Receptor 4, Hydrocortisone - Schrepf A, Bradley CS, O'Donnell M, Luo Y, Harte SE, Kreder K, Lutgendorf S; Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. Toll-like receptor 4 and comorbid pain in Interstitial Cystitis/Bladder Pain Syndrome: a multidisciplinary approach to the study of chronic pelvic pain research network study. Brain Behav Immun. 2015 Oct;49:66-74. doi: 10.1016/j.bbi.2015.03.003. Epub 2015 Mar 11. [PMID: 25771510] [PMC4567436]
Keywords: Functional somatic syndromes; Inflammation; Interstitial Cystitis/Bladder Pain Syndrome; Negative affect; Pain; Toll-like Receptors. - Sutcliffe S, Bradley CS, Clemens JQ, James AS, Konkle KS, Kreder KJ, Lai HH, Mackey SC, Ashe-McNalley CP, Rodriguez LV, Barrell E, Hou X, Robinson NA, Mullins C, Berry SH. Urological chronic pelvic pain syndrome flares and their impact: qualitative analysis in the MAPP network. Int Urogynecol J. 2015 Jul;26(7):1047-60. doi: 10.1007/s00192-015-2652-6. Epub 2015 Mar 20. [PMID: 25792349] [PMC4489981]
Keywords: Urological chronic pelvic pain syndrome; Interstitial cystitis; Bladder pain syndrome; Symptom exacerbation; Flare; Focus group. - Clemens JQ, Clauw DJ, Kreder K, Krieger JN, Kusek JW, Lai HH, Rodriguez L, Williams DA, Hou X, Stephens A, Landis JR; MAPP Research Network. Comparison of baseline urological symptoms in men and women in the MAPP research cohort. J Urol. 2015 May;193(5):1554-8. doi: 10.1016/j.juro.2014.11.016. Epub 2014 Nov 13. [PMID: 25463989] [PMC4454891]
Keywords: chronic pain; cystitis; interstitial; pelvic pain; prostatitis. - Krieger JN, Stephens AJ, Landis JR, Clemens JQ, Kreder K, Lai HH, Afari N, Rodríguez L, Schaeffer A, Mackey S, Andriole GL, Williams DA; MAPP Research Network. Relationship between chronic nonurological associated somatic syndromes and symptom severity in urological chronic pelvic pain syndromes: baseline evaluation of the MAPP study. J Urol. 2015 Apr;193(4):1254-62. doi: 10.1016/j.juro.2014.10.086. Epub 2014 Oct 22. [PMID: 25444992] [PMC4497586]
Keywords: cystitis; female; interstitial; male; questionnaires; urinary bladder. - Schrepf A, O'Donnell M, Luo Y, Bradley CS, Kreder K, Lutgendorf S; Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. Inflammation and inflammatory control in interstitial cystitis/bladder pain syndrome: Associations with painful symptoms. Pain. 2014 Sep;155(9):1755-1761. doi: 10.1016/j.pain.2014.05.029. Epub 2014 Jun 5. [PMID: 24907404] [PMC4166494]
Keywords: Bladder pain syndrome; Hypothalamic–pituitary–adrenal axis; Inflammation; Interstitial cystitis; Pelvic pain; Toll-like receptors. - Clemens JQ, Mullins C, Kusek JW, Kirkali Z, Mayer EA, Rodríguez LV, Klumpp DJ, Schaeffer AJ, Kreder KJ, Buchwald D, Andriole GL, Lucia MS, Landis JR, Clauw DJ; MAPP Research Network Study Group. The MAPP research network: a novel study of urologic chronic pelvic pain syndromes. BMC Urol. 2014 Aug 1;14:57. doi: 10.1186/1471-2490-14-57. [PMID: 25085007] [PMC4134515]
Keywords: Urological chronic pelvic pain syndromes; Interstitial cystitis; Chronic prostatitis; Translational research; Multi-disciplinary. - Landis JR, Williams DA, Lucia MS, Clauw DJ, Naliboff BD, Robinson NA, van Bokhoven A, Sutcliffe S, Schaeffer AJ, Rodriguez LV, Mayer EA, Lai HH, Krieger JN, Kreder KJ, Afari N, Andriole GL, Bradley CS, Griffith JW, Klumpp DJ, Hong BA, Lutgendorf SK, Buchwald D, Yang CC, Mackey S, Pontari MA, Hanno P, Kusek JW, Mullins C, Clemens JQ; MAPP Research Network Study Group. The MAPP research network: design, patient characterization and operations. BMC Urol. 2014 Aug 1;14:58. doi: 10.1186/1471-2490-14-58. [PMID: 25085119] [PMC4126395]
Keywords: Urologic chronic pelvic pain syndromes; Interstitial cystitis; Chronic prostatitis; Urine biomarkers; Plasma biomarkers; Non-urologic associated syndromes; Quantitative sensory testing (QST); Neuroimaging. - Kim R, Liu W, Chen X, Kreder KJ, Luo Y. Intravesical dimethyl sulfoxide inhibits acute and chronic bladder inflammation in transgenic experimental autoimmune cystitis models. J Biomed Biotechnol. 2011:937061. doi: 10.1155/2011/937061. Epub 2010 Nov 11. [PMID: 21113298] [PMC2989383]
Keywords: acute disease; autoimmune diseases; chronic disease; cystitis; dimethyl sulfoxide; dose-response relationship; epitopes; spleen/cytology; urinary bladder diseases.